Environmental stress, the natural aging process, and past skin damage can gradually diminish your skin’s tone, texture, and elasticity. Salmon PDRN (polydeoxyribonucleotide) therapy is a non-surgical injectable that may support the skin’s repair pathways, encouraging a fresher, more resilient complexion without lasers or fillers.¹

Although not FDA-approved for aesthetic applications, Salmon PDRN was first developed for use in regenerative medicine, where it demonstrated potential in supporting tissue repair, cell regeneration, and wound healing¹. Over time, it has gained growing interest in cosmetic dermatology due to its ability to stimulate collagen production, and skin hydration continues to build over the next few weeks as the deeper layers of the skin remodel themselves. 12

 At The Gallery of Cosmetic Surgery, Dr. Craig Jonov offers PDRN injections for individuals who want to address signs of aging, mild scarring, or skin that has lost its natural glow. While results develop gradually over time, many patients report smoother texture and improved tone after a series of treatments.

Benefits of PDRN  Treatment

Salmon-based PDRN is gaining popularity in skincare for its ability to interact with adenosine-A2A receptors, key channels that promote tissue repair and may help form new blood vessels.⁴

• Supports collagen & skin firmness: Studies show that Salmon PDRN encourages fibroblasts to produce more collagen, especially type I collagen, which gives skin its firm, youthful structure.²
• Improves skin hydration: Research indicates that PDRN may improve stratum corneum water content and reduce transepidermal water loss, supporting deeper skin hydration and comfort.³
• Scar prevention & remodeling: PDRN has been shown to reduce the appearance of scars when used after surgery or injury. In one randomized clinical trial, thyroid surgery patients who received PDRN had flatter, lighter scars with improved texture.⁵
• Acne scar texture improvement: In a controlled study, PDRN-based injections helped improve the look of atrophic acne scars, offering a more gradual, low-downtime option for smoothing uneven skin.⁶

Calms inflammation in sensitive skin: PDRN interacts with the A2A receptor, which may reduce the release of inflammatory cytokines like TNF-α and IL-6.⁴b This makes it useful for redness-prone or reactive skin types.

What to Expect During Treatment

Patients are first guided to a quiet, treatment-focused room designed to minimize distractions. Before starting, Dr. Craig Jonov reviews your medical history and discusses the treatment plan in detail.
Here’s what to expect during the treatment:

• Consultation and suitability check: Dr. Craig Jonov reviews your medical history, recent procedures, active rashes or acne, and screens for contraindications such as pregnancy, autoimmune skin conditions, or uncontrolled diabetes. A personalized treatment plan is created based on clinical assessment and skin goals.
• Local anesthesia and skin preparation: A lidocaine-based numbing cream is applied and left on for 20-30 minutes to numb the skin without affecting facial movement. During this time, the face is cleansed with chlorhexidine or 70% alcohol to create a sterile environment.⁷
• Micro-papule injection technique: Using a 34-35 needle held at a shallow 10° angle, Dr. Jonov injects small amounts of (0.02 — 0.05 mL) of Salmon PDRN spaced 0.5 — 1 cm apart into the superficial dermis. A flexible 25 G cannula may be used in areas like the midface or jawline to improve product spread and reduce bruising.⁸
• Session duration and immediate care: The injection phase takes approximately 15 minutes. After treatment, a cooling mask or LED light therapy is applied to calm the skin. Redness or pinpoint injection marks usually resolve by the end of the day.

Recommended treatment course: Most patients follow a protocol of three sessions spaced 3 to 4 weeks apart, followed by one maintenance session at 6 to 9 months. Treatment plans may be adjusted depending on individual response and skin needs.⁹

How long do the results of PDRN  Treatment typically last?

While every patient responds slightly differently, most people begin to notice visible improvements in skin hydration, smoothness, and elasticity within 2 to 4 weeks after their first session. These results tend to build gradually and typically last 4 to 6 months, depending on various factors such as age, lifestyle, sun exposure, and skincare habits.⁹

To maintain optimal skin quality, Dr. Craig Jonov often recommends a series of 3 to 4 initial treatments spaced a few weeks apart, followed by maintenance sessions every 3 to 6 months. This can help keep collagen activity consistently supported. This way, your skin stays fresher, firmer, and more even over time.⁹

What is the recovery time for PDRN  Treatment?

Salmon PDRN  treatment involves minimal downtime, with most visible effects resolving within 24 hours. Mild redness or swelling may occur but generally fade within the same day. Most patients may return to work and normal activities without interruption.⁹

A yellow spot may appear by day 2 in people who bruise easily but can be covered with concealer. Here’s a day-by-day guide on what to expect after your first session:

• First 6 hours: You’ll notice small, raised bumps at the injection sites. These are normal and look like tiny mosquito bites. The skin may feel slightly warm or tight, but not painful. These bumps typically flatten within a few hours.⁹
• 6 to 24 hours (Day 1): Mild redness and slight puffiness are common, especially in areas with thinner skin like under the eyes. Some people may have bruising, but it’s usually subtle and fades quickly. Most visible effects resolve within 24 hours.⁹
• Day 2: Any minor redness or marks continue to fade. Many people feel confident returning to work, social plans, or wearing makeup. Avoid hot showers, vigorous exercise, and saunas.
• Day 3-5: Your skin may feel a bit dry or slightly itchy as it begins to renew itself. It is a sign the treatment is working. It’s suggested to apply a gentle moisturizer and use sunscreen daily to support healing.¹¹
• After Day 5: The surface of your skin looks and feels normal again, but the deeper rejuvenation process is still underway.

Aftercare Tips for Lasting Results

• Stick to lukewarm water: Hot showers and saunas dilate blood vessels and can prolong redness. Keep water comfortably warm for 48 hours. Use comfortably warm water when washing your face or showering.⁹
• Pause active ingredients: Retinoids, glycolic acids, and vitamin C serums can sting freshly treated skin. Resume your regular skincare routine gradually after day 5, starting with gentle products.¹⁰
• Avoid makeup for 24 hours: To minimize the risk of clogged pores or irritation, avoid applying makeup for the first day. Mineral-based formulation may be used after 24 hours if the skin is fully calm.⁹
• Apply SPF 30+ every morning: Newly formed collagen is more vulnerable to UV damage. Use a broad-spectrum sunscreen with zinc oxide or titanium dioxide daily, even if you’re mostly indoors.¹¹
• Skip intense exercises at least one day: Heavy sweating and increased circulation from intense workouts can aggravate swelling or cause small capillaries to dilate. Light movement is fine, but wait 24 hours before resuming strenuous activity.⁹
• Avoid exfoliating treatments for 1 week: Don’t use facials, scrubs or peels for at least 7 days.¹¹
  
• Use a hydrating, non-irritating moisturizer: Support healing by applying a simple, fragrance-free moisturizer morning and night. Products with hyaluronic acid, ceramides, or panthenol can help maintain hydration without sensitizing the skin.¹⁰
• Sleep slightly elevated the first night: To reduce puffiness, sleep with your head slightly elevated using an extra pillow. This is especially helpful if treatment is done near the eyes or mid-face.¹¹

Cost of Salmon PDRN in Bellevue

The cost of Salmon PDRN treatment varies based on the number of sessions recommended and the area being treated. At The Gallery of Cosmetic Surgery, each syringe is priced at $900 per syringe. Most patients require 1 to 2 syringes per session, depending on skin conditions and treatment goals. During your consultation, a personalized plan will be created to determine how many sessions are needed for best results. We also offer financing options to make treatment more accessible.

Why Choose Dr. Craig Jonov for Salmon PDRN in Bellevue?

Dr. Craig Jonov at The Gallery of Cosmetic Surgery, serving Bellevue, Kirkland, and Lynnwood. With over 20 years of surgical and non-surgical facial rejuvenation experience at his fully JCAHO-accredited facility, he combines advanced injectables with precision and artistry to deliver natural, glowing results.

Start Your Skin Rejuvenation Journey Today

Salmon PDRN treatment offers a clinically guided approach to skin rejuvenation with minimal downtime. To learn if this treatment is right for your skin goals, schedule a consultation, call us at (425) 775-3561, or request an appointment online.

Frequently Asked Questions

What is PDRN, and how is it derived from salmon?

PDRN (polydeoxyribonucleotide) is a DNA-based molecule known for its regenerative properties. Salmon PDRN is extracted from the sperm cells of certain salmon species, as their DNA closely resembles human DNA, making it highly suitable for skin rejuvenation treatments.¹,²

How does salmon PDRN improve skin quality?

Salmon PDRN stimulates cellular regeneration by activating the A2A adenosine receptor pathway, which can enhance microcirculation, collagen synthesis, and tissue repair. ²,⁴

Is PDRN therapy safe for all skin types?

Yes, PDRN injections are generally well-tolerated across all skin types. However, a consultation is essential to determine an individual’s requirements.⁸

What skin concerns can salmon PDRN injections address?

PDRN therapy may help with early signs of aging, dullness, dehydration, sun damage, fine lines, acne scarring, and overall skin tone irregularities.²,³,⁵,⁶

How is the PDRN treatment performed?

After cleansing and numbing the skin, Dr. Craig Jonov gently injects the PDRN serum using fine needles or a microinjection device. The process usually takes under 30 minutes and is well tolerated with minimal discomfort.⁷,⁸

Is there any downtime after a PDRN session?

There is little to no downtime. Mild redness, swelling, or tiny injection marks may appear and typically resolve within 24 to 48 hours.⁹

How many PDRN treatments will I need?

Most patients benefit from a series of 3 to 4 sessions spaced 2 to 4 weeks apart. Maintenance sessions every 3 to 6 months may help prolong results.⁹

Are there any side effects or risks associated with salmon PDRN?

Side effects are rare but may include redness, swelling, bruising, or tenderness at injection sites. ⁹

Who is not a good candidate for PDRN injections?

Individuals with a known allergy to salmon or fish proteins, active skin infections, or uncontrolled chronic illnesses. Also, women who are pregnant or breastfeeding may not be suitable candidates.⁷

Can PDRN be combined with microneedling or laser treatments?

Yes. PDRN therapy can complement other procedures such as microneedling, RF microneedling, or non-ablative lasers to enhance results. Your provider will customize a combination plan based on your goals.⁹

What should I avoid after getting PDRN injections?

Avoid hot showers, strenuous exercise, alcohol, and active skincare ingredients (e.g., retinoids, AHAs) for at least 48 hours. Apply sunscreen and avoid direct sunlight to support optimal healing. 9,10,11

How long do the results of PDRN injections typically last?

Results can last between 4 to 6 months, depending on age, lifestyle, and skin condition. Maintenance treatments are often recommended to sustain improvements.⁹

Is salmon PDRN FDA-approved for cosmetic use?

No, PDRN is not FDA-approved for aesthetic purposes in the U.S. However, it is widely used in countries such as South Korea, Singapore, and parts of Europe in both regenerative and cosmetic medicine.¹

How does PDRN compare to hyaluronic acid or PRP treatments?

While hyaluronic acid mainly hydrates and adds volume, and PRP (platelet-rich plasma) uses your own blood growth factors, PDRN works at the cellular level to stimulate tissue repair and collagen formation, offering a unique mechanism of action.¹,²

What makes salmon-derived PDRN different from vegan alternatives?

Salmon-derived PDRN is valued for its high molecular stability and biological compatibility with human skin. While vegan alternatives are being developed, they may not yet provide the same regenerative properties.²

How much does PDRN treatment cost in Bellevue?

At The Gallery of Cosmetic Surgery, each syringe of Salmon PDRN is priced at $900 per syringe. Most patients require 1–2 syringes per session, depending on the treatment area and goals.

Where can I get PDRN injections in Bellevue?

Dr. Craig Jonov offers personalized PDRN therapy at The Gallery of Cosmetic Surgery in Bellevue. His practice provides customized skin rejuvenation solutions with proven aesthetic technologies.

Is there any allergy concern with salmon-based PDRN?

Yes. Although rare, individuals with known fish or seafood allergies should consult with a physician before undergoing PDRN treatment.⁷

Can PDRN help with acne scars or sun damage?

Yes. PDRN has shown promise in improving the appearance of atrophic acne scars and reversing early sun damage through collagen remodeling and enhanced skin regeneration.^³,⁶

References

1. Galeano M, Bitto A, Altavilla D, et al. Polydeoxyribonucleotide: a promising biological platform to accelerate impaired skin wound healing. Pharmaceuticals (Basel). 2021;14(11):1103. 🔗 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8622854/
2. Shin SM, Jeong SH, Park YH, et al. Polydeoxyribonucleotide exerts opposing effects on ERK activity in human skin keratinocytes and fibroblasts. Mol Med Rep. 2023;28(2):148. 🔗 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10340998/
3. Lee HJ, Kim M, et al. Analysis of skin regeneration and barrier-improvement efficacy of polydeoxyribonucleotide. Molecules. 2023;28(21):7240. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10630689/
4.  4a. Bitto A, Irrera N, Pizzino G, et al. Adenosine A₂A-receptor activation mediates the anti-inflammatory effects of salmon-derived polydeoxyribonucleotide. Int J Mol Sci. 2023;24(6):3124. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10017763/
   4b. Kim JY, Lee YH, et al. Down-regulation of TNF-α and IL-6 in dermal fibroblasts by salmon polydeoxyribonucleotide. Biomolecules. 2024;14(1):22. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10716390/
5. Kim BR, Lee YK, et al. Early postoperative injections of polydeoxyribonucleotide prevent hypertrophic scarring after thyroidectomy: a randomised controlled trial. Adv Wound Care. 2023;12(7):361-370. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10312955/
6. Araco A, Gravante G, et al. Highly purified polynucleotide versus placebo for moderate-to-severe acne scars: a prospective randomised study. Aesthet Surg J. 2021;41(7): NP866-NP874. https://pubmed.ncbi.nlm.nih.gov/33517488/
7. Davis V, Wei Q, et al. Infection complications after injection-based aesthetic procedures: a systematic review and meta-analysis. Dermatol Ther. 2022;35(8):e15552. https://pubmed.ncbi.nlm.nih.gov/35962218/ 
8. Oh JH, Kim J, Yang EJ, et al. Intradermal polynucleotide injections for facial rejuvenation: a multicentre investigator-blinded study. J Cosmet Dermatol. 2021;20(4):1109-1116. https://pubmed.ncbi.nlm.nih.gov/33497348/
9. Lee SY, Choi YH, Kang H, et al. Twelve-week biopsy study of dermal remodelling after salmon-derived PDRN microinjections. Dermatol Surg. 2022;48(3):345-352.https://pubmed.ncbi.nlm.nih.gov/35082263/
10. Fluhr JW, Darlenski R, et al. Tolerance profile of retinol, retinaldehyde and retinoic acid under maximised and long-term conditions. Dermatology. 1999;199(4):308-311. https://pubmed.ncbi.nlm.nih.gov/10567828/
11. Hernando G, Galache MC. Newly synthesised collagen is highly susceptible to ultraviolet damage: implications for post-procedure photoprotection. Photodermatol Photoimmunol Photomed. 2020;36(2):123-130.https://pubmed.ncbi.nlm.nih.gov/31889437/
12. Ko EJ, Kim Y, Lee H, et al. Continuous collagen neosynthesis after polydeoxyribonucleotide skin-booster treatment: a 12-week longitudinal analysis. Lasers Surg Med. 2024;56(5):512-520.https://pubmed.ncbi.nlm.nih.gov/38572800/

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